Abcam, ab186743, Anti-HNF6 antibody [EPR14976]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HNF6 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14976,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hepatocyte nuclear factor 6 (HNF6) also known as Onecut1 is a transcription factor that functions to regulate gene expression. It has a molecular mass of approximately 55 kDa. HNF6 is expressed in the liver pancreas and several other tissues influencing the development and function of these organs. It plays a significant role in regulating genes involved in various cellular processes by binding to DNA sequences and controlling transcription.
Biological function summary
This transcription factor controls the development and maturation of pancreatic islets and hepatocytes. It does not usually function as part of a larger protein complex but it directly influences genes that are vital for these processes. HNF6 ensures proper liver cell differentiation and has an important role in managing glucose metabolism and bile acid homeostasis in tissues where it is expressed.
Pathways
Hepatocyte nuclear factor 6 is integral to the glucose metabolism and bile acid biosynthesis pathways. It interacts with other transcription factors such as HNF4α and FOXA2 forming a regulatory network. HNF6 affects gene expression involved in maintaining metabolic balance and liver detoxification processes illustrating its critical influence on metabolic function within these pathways.
HNF6 links to diabetes and liver diseases. Its modulation of pancreatic development and function implicates it in both type 1 and type 2 diabetes often involving its interaction with other transcription factors like PDX1 and MafA. Similarly changes in HNF6 expression affect liver diseases such as cholestasis where it impacts bile acid regulation and liver cell function.