Abcam, ab186750, Anti-MBIP antibody [EPR13951]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MBIP antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13951,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MBIP also known as Mps-One Binder kinase activator-like protein 1 acts mechanically by being a component of certain cellular complexes involved in intracellular signaling. It has a molecular mass of approximately 25 kDa. Expression of MBIP occurs in many tissues but it is found at higher levels in brain and kidney tissues suggesting its significant role in these areas.
Biological function summary
MBIP regulates signaling pathways that control cell growth development and differentiation. As a part of the c-Jun N-terminal kinase (JNK) signalosome complex MBIP influences pathways that mediate responses to stress and inflammatory stimuli. The presence of MBIP in these complexes emphasizes its role in modulating the cellular response to environmental changes shedding light on how it contributes to maintaining cellular homeostasis.
Pathways
MBIP functions within the JNK signaling and the domino effect on MAP kinase pathways. In the JNK pathway MBIP interacts closely with proteins such as MKK4 and JNKs to ensure proper signal transduction and cellular outcomes. Its activity helps mediate cellular responses modulating processes like apoptosis and cell survival indicating its importance in maintaining cellular balance and health.
MBIP shows relevance to conditions like cancer and neurodegenerative diseases. Aberrant MBIP expression or activity can disrupt the JNK pathway leading to uncontrolled cell proliferation in cancer or altered neuronal functioning in conditions like Alzheimer's disease. Connections between MBIP and other proteins such as JNKs and MKK4 highlight its influence on pathological developments in these disorders providing a critical link between cellular signaling and disease progression.