Abcam, ab187186, Anti-Protocadherin Gamma (pan) antibody [N159/5] - C-terminal

Size: 100µg
Mouse Monoclonal Protocadherin Gamma (pan) antibody. C-terminal. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N159/5,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Cross-reacts with all Gamma- protocadherin-A, -B and -C proteins.

Product details:
The clone number has been updated from S159-5 to N159/5, both clone numbers name the same antibody clone.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protocadherin Gamma (pan) also known as PCDH-γ is a member of the cadherin superfamily with a molecular weight of approximately 110 kDa. This protein is principally expressed in the central nervous system where it plays a significant role in neural differentiation and connectivity. Protocadherin Gamma consists of a clustered gene family which includes many isoforms classified into subgroups A B and C. This family exhibits diverse and complex expression at the neuronal cell surface contributing to neural circuit formation and maintenance.
Biological function summary
Clustered gene expression in the brain results in Protocadherin Gamma being necessary for cell-cell adhesion and signaling mechanisms. The protein organizes into tetramers that form large complexes essential for synaptic specificity. Protocadherin Gamma's interactions occur at the cellular membrane involving extracellular domains that mediate contact with neighboring cells. The protein cooperates with other members of the cadherin family reinforcing cellular adhesion and structural integrity in neural tissues.
Pathways
Functional interactions in neural development prominently involve Protocadherin Gamma. This protein is integrated into the neural circuit assembly and synaptic connection pathways ensuring proper communication within the brain. Protocadherin Gamma demonstrates links to signaling proteins like neural cell adhesion molecules which assist in transmitting extracellular signals to intracellular domains. These pathways play a role in regulating synaptic plasticity which is important for learning and memory processes.
Physiological imbalances or mutations in Protocadherin Gamma relate to conditions such as epilepsy and autism spectrum disorders. It interacts with scaffolding proteins which facilitate proper synapse formation essential for normal cognitive functions. Disruption in the expression or function of Protocadherin Gamma can lead to impaired neural connectivity contributing to the etiology of the aforementioned neurological conditions. Identifying pathophysiological changes in PCDH-γ expression may provide insights into therapeutic approaches for these disorders.