Abcam, ab187692, Anti-SLC1A5/ASCT2 antibody

Size: 100µg
Rabbit Polyclonal SLC1A5/ASCT2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human SLC1A5 aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC1A5 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.Q15758

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab187692 was affinity purified using an epitope specific to SLC1A5/ASCT2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SLC1A5 protein also known as ASCT2 is a sodium-dependent neutral amino acid transporter with a molecular mass of approximately 56 kDa. It plays an important role in the transport of amino acids such as glutamine across the plasma membrane. This transporter is widely expressed in multiple tissues including the liver brain and kidneys. ASCT2 is integral in maintaining amino acid balance within cells facilitating nutrient uptake essential for cellular metabolism and function.
Biological function summary
The SLC1A5 protein contributes to cellular processes by facilitating the uptake of neutral amino acids. ASCT2 operates as a part of a complex of transporters that ensure the supply of critical nutrients within cells impacting metabolic processes like protein synthesis and cell growth. Its function supports the dynamic needs of rapidly growing tissues and is especially active in conditions demanding high amino acid turnover.
Pathways
The activity of SLC1A5/ASCT2 is important in amino acid transport pathways particularly influencing the mTOR signaling which plays a significant role in cell growth and metabolic regulation. SLC1A5/ASCT2 interaction with proteins like LAT1 strengthens its involvement in these pathways. These interactions outline a network of nutrient sensing and metabolic control important for cellular proliferation and homeostasis.
SLC1A5/ASCT2 shows a significant connection to cancer as many cancer cells exploit its role in glutamine transport to fuel their rapid growth and survival. Additionally its involvement is noted in metabolic disorders where dysregulated amino acid transport can lead to imbalances in cellular metabolism. SLC1A5/ASCT2 has potential interactions with proteins like glutaminase which are often upregulated in oncogenic pathways highlighting its importance as a target for therapeutic interventions.