Abcam, ab188007, Anti-ITPKC antibody

Size: 100µL
Rabbit Polyclonal ITPKC antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ITPKC aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ITPKC aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q96DU7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ITPKC also known as inositol 145-trisphosphate 3-kinase C is an enzyme involved in the phosphorylation of inositol 145-trisphosphate (IP3) converting it into inositol 1345-tetrakisphosphate (IP4). This protein has a molecular mass of approximately 55 kDa and is expressed in various tissues including the heart brain and skeletal muscle. Its role in cellular signaling processes makes it an important target for research in multiple biological functions.
Biological function summary
The enzyme ITPKC plays an important role in calcium signaling by modulating intracellular calcium levels. It does not typically form a complex with other proteins but acts independently to regulate IP3 a secondary messenger critical for calcium release from the endoplasmic reticulum. This regulation affects processes such as muscle contraction cell growth and apoptosis. The enzyme's function in maintaining cellular calcium levels highlights its importance in various physiological contexts.
Pathways
ITPKC operates within the phosphoinositide pathway playing an important role in calcium signaling and homeostasis. The regulation of IP3 and IP4 levels by ITPKC impacts signal transduction pathways influencing activities like cell proliferation and immune responses. Key interactions occur with proteins such as IP3 receptors on the endoplasmic reticulum which facilitate calcium release and uptake into cellular compartments.
ITPKC influences the development of certain conditions such as Kawasaki disease and autoimmune disorders. Genetic variations in the ITPKC gene have been linked to an increased risk of Kawasaki disease a condition affecting blood vessels in children. In autoimmune diseases the altered regulation of calcium signaling pathways often involving proteins like calcineurin highlights the role of ITPKC in immune cell activation and inflammation. These associations emphasize the clinical importance of ITPKC in therapeutic research and potential treatments.