Abcam, ab188018, Anti-LRRN4CL antibody

Size: 100µL
Rabbit Polyclonal LRRN4CL antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRN4CL aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LRRN4CL aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8ND94

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein LRRN4CL also known as Leucine-Rich Repeat Neuronal 4C-Like plays a role in cellular signaling mechanisms. This protein has a mass of approximately 59 kDa and is expressed in neural tissues particularly within the central nervous system. LRRN4CL contains leucine-rich repeats that facilitate protein-protein interactions suggesting its involvement in complex cellular activities. Expression in the brain indicates its potential function in neural development or function.
Biological function summary
LRRN4CL is involved in neuronal differentiation and synaptic formation. The protein is part of the leucine-rich repeat protein family which mediates diverse cellular functions in neurons. LRRN4CL likely interacts with other neuronal proteins to promote synaptic connectivity. Additionally its location in brain tissues suggests a role in modulating neural pathways or responses during brain development or in mature neurons.
Pathways
LRRN4CL is involved in the neurodevelopmental signaling pathways like the Notch signaling pathway which is important for cell fate determination in neural stem cells. It interacts with proteins such as Notch receptors to influence neuronal differentiation. LRRN4CL plays a role in the Wnt signaling pathway which contributes to processes such as synaptic plasticity possibly through its interaction with components like beta-catenin.
LRRN4CL is associated with neurological conditions such as autism spectrum disorders (ASD) and schizophrenia. In ASD changes in LRRN4CL expression may disrupt normal synaptic function impacting cognitive and social behaviors. The protein's association with schizophrenia may involve altered signaling pathways related to synaptic neurotransmission. Changes in related proteins such as Notch receptors further suggest LRRN4CL's role in these disorders highlighting its importance in maintaining neural function and integrity.