Abcam, ab188321, Anti-ATIC antibody [EPR13243-53]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ATIC antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13243-53,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATIC also known as AICAR transformylase/IMP cyclohydrolase is a bifunctional enzyme involved in purine biosynthesis within cells. It has a molecular mass of approximately 64 kDa. This enzyme is found in various tissues including liver kidney and brain. It catalyzes the last two steps in the de novo purine biosynthesis pathway playing an important role in cellular proliferation and energy homeostasis.
Biological function summary
ATIC participates importantly in purine metabolism by facilitating the conversion of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) into inosine monophosphate (IMP). It acts both as a transformylase and cyclohydrolase forming part of the multi-enzyme purinosome complex. This involvement ensures efficient synthesis of IMP which is a precursor for adenosine and guanosine nucleotide production essential for DNA and RNA synthesis.
Pathways
ATIC is integral to the de novo purine biosynthesis pathway a critical cellular process for generating nucleotides. It interacts with other enzymes in this pathway such as phosphoribosylaminoimidazole carboxamide formyltransferase (PAIC) and adenylosuccinate lyase (ADSL) ensuring a steady supply of nucleotides. This pathway is also linked to the folate cycle highlighting the importance of ATIC in broader metabolic contexts.
ATIC has associations with several conditions notably cancer and autoimmune diseases. Its role in purine and folate metabolism makes it a target in cancer therapies where fast-dividing cells depend on nucleotide synthesis. ATIC also connects to dihydrofolate reductase (DHFR) due to the shared pathway implicating both in therapies aimed at autoimmune conditions like rheumatoid arthritis. Understanding ATIC's function and interaction plays a part in advancing disease treatment strategies.