Abcam, ab188326, Anti-C14orf166 antibody [EPR15799]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal C14orf166 antibody. Suitable for IP, WB, ICC/IF, IHC-P and reacts with Human, Rat, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15799,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C14orf166 also known as TIPH2 is a protein encoded by the C14orf166 gene. This protein has a molecular mass of approximately 38 kDa. It plays a role in RNA metabolism particularly in the export of messenger RNA (mRNA) from the nucleus to the cytoplasm. Expression of C14orf166 occurs in various tissues with higher levels often found in actively dividing and metabolically active cells.
Biological function summary
C14orf166 integrates into the transcriptional regulation process by forming part of a complex involved in RNA processing. It interacts with components of the transcription-export (TREX) complex which is essential for coupling mRNA processing with export. This integration allows C14orf166 to assist in maintaining efficient mRNA transport and translation important for normal cellular function and stress response.
Pathways
C14orf166 significantly influences gene expression regulation and participates in the mRNA processing pathways. It interacts with proteins such as Aly/REF and UAP56 within the TREX complex importantly impacting the efficiency of mRNA export. By securing efficient mRNA transport C14orf166 supports critical biological pathways like the unfolded protein response and cellular proliferation.
Aberrant expression or function of C14orf166 has connections to cancer particularly breast cancer. Dysregulation in its function can lead to improper mRNA export contributing to tumorigenesis. Furthermore C14orf166 shows relations to viral infections; for example it intersects with pathways involving Nucleophosmin (NPM1) which are exploited by viruses such as influenza. This makes C14orf166 a potential target for therapeutic strategies aiming to manage these conditions.