Abcam, ab188407, Anti-DMAP1 antibody [EPR18179]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DMAP1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18179,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DMAP1 also known as DNA methyltransferase 1-associated protein 1 functions mechanically as a regulatory component in several cellular processes. With an approximate mass of 53 kDa this protein exhibits widespread expression in various tissues reflecting its diverse roles within the cell. The primary function of DMAP1 involves transcriptional regulation through histone modification and chromatin remodeling influencing gene expression patterns.
Biological function summary
DMAP1 participates in gene silencing and regulation through integration into the NuRD complex a critical multi-subunit complex involved in chromatin remodeling and deacetylation of histones. By modulating chromatin structure DMAP1 influences DNA accessibility and transcriptional activation or repression. This protein provides a scaffold for the recruitment of additional factors essential for transcriptional regulatory complexes further enhancing its role in maintaining cellular homeostasis.
Pathways
DMAP1 plays a significant role in the DNA damage response and repair pathways particularly through its interactions with proteins such as DNA methyltransferase 1 (DNMT1) and components of the NuRD complex. Through these interactions DMAP1 aids in the repair of damaged DNA and maintenance of genomic stability. This involvement highlights its connection to cellular processes like cell cycle control and development linking it to broader biological networks.
DMAP1 displays associations with various cancers and neurological disorders reflecting its importance in maintaining proper cellular function. Aberrations in DMAP1 activity or expression have been observed in certain cancers where its interaction with proteins like DNMT1 and components of chromatin remodeling complexes may contribute to tumorigenesis. Similarly its disruption can affect neurodevelopmental processes possibly linking it to neurodegenerative diseases. Understanding DMAP1's role in these conditions can provide insights into therapeutic targets and disease mechanisms.