Abcam, ab188506, Recombinant Human LIPG protein

Size: 100µg
Recombinant Human LIPG protein is a Human Full Length protein, in the 21 to 500 aa range, expressed in HEK 293 cells, with >85%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, ELISA, Mass Spec.
Key facts
Purity:>85% Densitometry,
Endotoxin level:< 1 EU/µg,
Expression system:HEK 293 cells,
Tags:His tag C-Terminus,
Applications:SDS-PAGE, ELISA, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9Y5X9,
Animal free:No,
Carrier free:No,
Species:Human,
Reconstitution:Reconstitute in 200 µL of water,
Storage buffer:Constituents: PBS, 4% Mannitol, 1% Sucrose

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIPG also known as endothelial lipase or the LIPG protein is an important enzyme involved in lipid metabolism. It belongs to the triglyceride lipase gene family and is mainly responsible for hydrolyzing phospholipids. The protein has a mass of about 55 kDa and is expressed primarily in endothelial cells that line blood vessels but also found in other tissues like the liver and lungs. This enzyme plays a role in cholesterol metabolism by impacting high-density lipoprotein (HDL) cholesterol levels influencing cardiovascular health.
Biological function summary
LIPG protein serves a role in lipid and lipoprotein metabolism. It does not operate as part of a larger complex but influences the remodeling of high-density lipoproteins by hydrolyzing their phospholipid content. By doing so LIPG helps regulate the levels and distribution of lipoproteins in circulation. This can affect the levels of free fatty acids and consequently influence energy homeostasis.
Pathways
LIPG protein participates in the lipoprotein metabolism and cholesterol transport pathways. It acts alongside other lipases such as hepatic lipase and lipoprotein lipase to maintain lipid homeostasis. These pathways are critical for the mobilization and distribution of fatty acids and cholesterol in the body. LIPG's modulation of HDL cholesterol levels links it to pathways of both cardiovascular and metabolic health through interactions with cholesterol transport proteins.
LIPG protein is closely associated with atherosclerosis and cardiovascular diseases. Altered activity or expression of LIPG can contribute to the development of these conditions by affecting HDL cholesterol levels. Disease pathways involve its interaction with other proteins such as ApoA-I a major component of HDL which impacts lipid transport and cardiovascular risk. Understanding LIPG's role in these disorders can potentially lead to new therapeutic approaches targeting lipid metabolism.