Abcam, ab189034, Anti-CDKN2A/p16INK4a antibody - N-terminal

Size: 50µL
Anti-CDKN2A/p16INK4a antibody - N-terminal (ab189034) is a rabbit polyclonal antibody detecting CDKN2A/p16INK4a in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse . - Over 70 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CDKN2A. The exact immunogen used to generate this antibody is proprietary information.P42771,
Specificity:Expression levels of the CDKN2A/p16INK4a protein may vary with sample type. It's barely expressed in normal tissue, and mostly expressed in some tumour tissues, such as cervical cancer, breast cancer and so on. Moreover, only expressed in some cell lines. Please see images for recommended positive controls.

Product details:
Product Specifications
Anti-CDKN2A/p16INK4a antibody - N-terminal (ab189034) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse samples.
Anti-CDKN2A/p16INK4a antibody - N-terminal (ab189034) specifically detects CDKN2A/p16INK4a (UniProt ID: P42771; Molecular weight: 17kDa) and is sold in 50 µL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-CDKN2A/p16INK4a antibody - N-terminal (ab189034) has high sensitivity and specificity.
Anti-CDKN2A/p16INK4a antibody - N-terminal (ab189034) has been cited over 72 times in peer reviewed journals and is trusted by the scientific community.
Anti-CDKN2A/p16INK4a antibody - N-terminal (ab189034) has 4 independent reviews from customers.
Target Information
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a crucial tumor suppressor gene located on chromosome 9p211. It encodes two proteins, p16INK4a and p14ARF, both of which play significant roles in regulating the cell cycle. p16INK4a inhibits cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), preventing the progression from the G1 to S phase of the cell cycle. This inhibition is vital for controlling cell proliferation and preventing tumor growth. Mutations or deletions in CDKN2A are frequently associated with various cancers, including melanoma, pancreatic cancer, and head and neck squamous cell carcinoma.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle