Abcam, ab189202, Anti-Nkx2.4 antibody

Size: 50µg
Rabbit Polyclonal Nkx2.4 antibody. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human NKX2-4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC, IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NKX2-4. The exact immunogen used to generate this antibody is proprietary information.Q9H2Z4,
Specificity:ab189202 is predicted to not cross-react with other NK2 homeobox family members. At least two isoforms of Nkx2.4 are known to exist; this antibody will detect both isoforms.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nkx2.4 also known as a homeobox protein Nkx-2.4 is a transcription factor that influences gene expression important for developmental processes. This protein has a molecular mass of approximately 29 kDa. Nkx2.4 expression occurs mainly in the developing neural tissues and some other tissues during embryogenesis. Researchers find it critical in the patterning and differentiation of these tissues often interacting with DNA sequences to regulate specific gene expression.
Biological function summary
Nkx2.4 contributes to neural differentiation and development. It acts independently or in conjunction with other proteins as part of larger transcriptional complexes. These complexes ensure proper progression in developmental processes as Nkx2.4 guides target gene expression during early development. Its involvement is linked to controlling the formation of various neural structures demonstrating its fundamental role in embryonic development.
Pathways
Nkx2.4 is important in the formation and differentiation within the Wnt signaling and Notch pathways. It collaborates with other proteins like Sox2 and Pax6 performing specific roles that aid in defining the development of neural cells. Nkx2.4 regulates genes situating early in these pathways guiding cell-fate decisions and structural development during embryogenesis.
Nkx2.4's malfunction links to neurological disorders and developmental abnormalities. Misregulation or mutations in Nkx2.4 have associations with certain congenital conditions affecting the neural system. It also interacts with proteins such as Lhx3 in disease contexts emphasizing the need for proper Nkx2.4 function to ensure typical neural development and maintain health.