Abcam, ab189953, Anti-Pellino 1 antibody - C-terminal

Size: 50µg
Rabbit Polyclonal Pellino 1 antibody. C-terminal. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PELI1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PELI1. The exact immunogen used to generate this antibody is proprietary information.Q96FA3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pellino 1 is an E3 ubiquitin ligase important in signaling pathways linked to immune response and inflammation. It is also known as RNF232 and has a molecular weight of approximately 41 kDa. You can find expression of Pellino 1 in various tissues including immune cells like macrophages and dendritic cells. Its activity relies on its ability to add ubiquitin moieties to target proteins a process essential for tagging these proteins for cellular processes like degradation or trafficking.
Biological function summary
Pellino 1 plays a major role in immune signaling networks. It acts as an adaptor and signal transducer which facilitates the recruitment and regulation of other signaling molecules. It often forms part of a signaling complex within the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) pathways. The complex assembly enables Pellino 1 to modulate innate immune responses by influencing downstream signaling events that elevate inflammatory cytokine production and immune cell activation.
Pathways
Pellino 1 participates significantly in the TLR and IL-1R signaling pathways. These pathways are critical for activating nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways enabling transcription of immune-related genes. In the TLR pathway Pellino 1 functions alongside proteins such as IRAK1 modulating pathway outcomes by regulating the ubiquitination of downstream signaling components.
Pellino 1 frequently associates with autoimmune diseases and chronic inflammatory conditions. Its role in modulating immune responses links it to conditions such as rheumatoid arthritis where it influences the inflammatory response through interactions with key proteins like TRAF6. Aberrations in Pellino 1 function or expression have also connections to systemic lupus erythematosus as its regulation of NF-κB signaling affects autoantibody production and inflammatory cell survival.