Abcam, ab189955, Anti-SCUBE3 antibody

Size: 50µg
Rabbit Polyclonal SCUBE3 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SCUBE3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SCUBE3. The exact immunogen used to generate this antibody is proprietary information.Q8IX30,
Specificity:At least two isoforms of SCUBE3 are known to exist. SCUBE3 antibody is predicted to not cross-react with other SCUBE members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein SCUBE3 also known as Signal Peptide CUB domain and Epidermal Growth Factor-like domain-containing protein 3 is a member of the SCUBE family. It is characterized by its mass of approximately 110 kDa. SCUBE3 is primarily expressed in various tissues including kidney lung heart and bone. Structurally it has important domains such as CUB and EGF-like domains that assist in its interaction with different molecules in the extracellular environment.
Biological function summary
SCUBE3 functions as a coreceptor playing a significant role in modulating developmental and morphogenetic processes. It is part of a complex involved in cell signaling enhancing interactions between growth factors and their receptors. Through these interactions SCUBE3 regulates cell proliferation differentiation and movement essential in embryonic development and tissue homeostasis.
Pathways
SCUBE3 plays a role in critical signaling pathways such as the Hedgehog and transforming growth factor-beta (TGF-β) pathways. It interacts with proteins like Smoothened (Smo) in the Hedgehog pathway and TGF-β receptors influencing cellular responses. By modulating these pathways SCUBE3 contributes to signaling cascades that are important for organ development and tissue repair.
SCUBE3 relates to pulmonary fibrosis and cancer. It has a connection with proteins like fibroblast growth factor (FGF) in these conditions. In pulmonary fibrosis aberrant SCUBE3 activity influences fibroblast proliferation and extracellular matrix deposition. In cancer particularly in aggressive tumor types SCUBE3's role in enhancing growth factor signaling can contribute to uncontrolled cell growth and metastasis.