Abcam, ab190087, Anti-SFTPA1 + SFTPA2 antibody

Size: 50µg
Goat Polyclonal Pulmonary surfactant-associated protein A1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SFTPA1 aa 100-150.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SFTPA1 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.Q8IWL2,
Specificity:ab190087 is expected to recognize all the reported isoforms of A1 (NP_005402.3; NP_001087239.2; NP_001158117.1; NP_001158118.1) and A2 ( NP_001092138.1), Reported variants represent identical protein: NP_001158116.1, NP_005402.3, NP_001158119.1.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SFTPA1 and SFTPA2 also known as Surfactant Protein A1 and Surfactant Protein A2 are important components of the pulmonary surfactant system. These proteins have masses of approximately 26 kDa each. They are expressed in alveolar type II cells in the lungs and are secreted into the alveolar space. The primary function of SFTPA1 and SFTPA2 is to reduce surface tension in the alveoli preventing collapse during exhalation and supporting efficient gas exchange.
Biological function summary
Surfactant Proteins A1 and A2 play essential roles in the immune defense of the lungs. They operate as part of the surfactant protein complex which includes other proteins like SP-B SP-C and SP-D. They bind to various pathogens including bacteria and viruses promoting their clearance by enhancing phagocytosis by alveolar macrophages. This immune function is vital for maintaining pulmonary health and protecting against infections.
Pathways
These proteins function within the innate immune response and inflammation pathways in the lung. In these pathways SFTPA1 and SFTPA2 interact with toll-like receptors (TLRs) and CD14 binding to pattern recognition receptors (PRRs) to initiate defense reactions against pathogens. Their action complements other immune proteins like Mannose-Binding Lectin (MBL) and is linked with receptor-mediated pathways that modulate inflammation and immunity in the respiratory system.
Improperly functioning Surfactant Proteins A can lead to respiratory distress syndromes such as neonatal respiratory distress syndrome and acute respiratory distress syndrome. Mutations or deficiencies in these proteins have association with interstitial lung disease. Changes or dysregulation of SFTPA1 and SFTPA2 levels can alter lung immunity creating a link with inflammatory responses and diseases influenced by SP-D and related surfactant proteins.