Abcam, ab190251, Anti-COX16 antibody

Size: 100µL
Rabbit Polyclonal COX16 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human COX16 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human COX16 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9P0S2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX16 also known as cytochrome c oxidase assembly factor COX16 is a mitochondrial membrane protein with a molecular mass of approximately 16 kDa. This protein is expressed primarily in tissues with high energy demands such as skeletal muscles heart and brain. It resides in the inner mitochondrial membrane where it assists in the stabilization and assembly of cytochrome c oxidase an important component of the mitochondrial respiratory chain.
Biological function summary
COX16 plays a role in facilitating the assembly of cytochrome c oxidase which is a multi-subunit complex. This enzyme complex is responsible for the final step in the electron transport chain a process critical for ATP production in cells. COX16 contributes to the incorporation of subunit Cox1 into the growing enzyme complex ensuring proper enzyme functionality and cellular energy production.
Pathways
COX16 is integral to mitochondrial oxidative phosphorylation and respiratory chain complexes formation. It interacts closely with other proteins such as SURF1 and LRPPRC which are also involved in cytochrome c oxidase assembly. Dysfunction in these pathways can lead to impaired energy production and metabolic disturbances at the cellular level.
COX16 mutations have been linked to disorders like mitochondrial complex IV deficiency and Leigh syndrome. These diseases manifest with neurological and muscular symptoms due to impaired energy metabolism. COX16's dysfunction in these conditions often involves interactions with proteins like COX10 and COX2 further implicating the cytochrome oxidase complex's role in disease pathology.