Abcam, ab190289, Anti-c-Fos antibody - BSA free

Size: 100µL
Anti-c-Fos antibody - BSA free (ab190289) is a rabbit polyclonal antibody detecting c-Fos in Western Blot, IHC-P, IHC-FrFl, ICC/IF . Suitable for Human, Mouse, Rat . - BSA free for higher signal-to noise ratio - Over 210 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-FrFl, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human FOS.P01100

Product details:
Anti-c-Fos antibody - BSA free (ab190289) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-FrFl, IHC-P and WB.
Anti-c-Fos antibody - BSA free (ab190289) was first used in a scientific publication in 2015 and has been cited over 216 times in peer reviewed journals. It's performance in IHC in mouse and rat samples is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-c-Fos antibody - BSA free (ab190289) has high sensitivity and specificity.
Anti-c-Fos antibody - BSA free (ab190289) has 8 independent reviews from customers.
Anti-c-Fos antibody - BSA free (ab190289) specifically detects c-Fos (UniProt ID: P01100; Molecular weight: 41kDa) and is sold in 100 µL selling sizes.
c-Fos is an immediate-early gene widely used in neuro research for its role as a marker of neuronal activation. It is rapidly expressed in response to various stimuli, making it an excellent indicator of neuronal activity and functional mapping. Researchers use c-Fos to study brain activity patterns, synaptic plasticity and the effects of drugs or other interventions on the central nervous system, making it essential for understanding dynamic changes in brain function.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.033% Sodium azideConstituents: PBS, 49.9% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C-Fos is a well-known transcription factor that plays important roles in cellular functions. It belongs to the Fos family of proteins and is also known by the names Fos or cfos. The molecular weight of c-Fos is approximately 62 kDa. This protein is expressed in various tissues including the brain where it frequently appears in neurons. Researchers often use techniques like c-fos staining and cfos immunohistochemistry to visualize its expression patterns in tissue samples. The protein interacts with DNA to regulate the transcription of target genes influencing a wide range of cellular processes.
Biological function summary
C-Fos forms a complex with the protein c-Jun creating the AP-1 transcription factor. This complex binds to specific DNA sequences modulating gene expression in response to various stimuli such as growth factors stress and cytokines. The specific gene targets controlled by AP-1 can lead to cell proliferation differentiation or apoptosis depending on the context within a biological system. Through its actions c-Fos significantly affects gene expression patterns helping cells adapt to their environment.
Pathways
C-Fos takes part in the MAPK/ERK pathway and the JNK pathway both critical for transmitting signals from the cell surface to the nucleus. c-Fos upregulates genes that contribute to cell cycle progression and survival. In the MAPK/ERK pathway interaction with proteins such as MEK and ERK leads to c-Fos activation. In the JNK pathway c-Fos often works together with JNK protein to influence cellular responses to stress. These pathways position c-Fos as an important player in regulating cell fate decisions and responses to extracellular signals.
Altered c-Fos expression relates to cancer and neurological disorders. In many cancer types elevated levels of c-Fos contribute to increased cell proliferation and reduced apoptosis making it a marker for tumorigenesis. In the context of neurological disorders aberrant regulation of c-Fos and its interaction with other proteins like c-Jun and ATF2 can lead to neurodegenerative diseases. Researchers study c-Fos to understand its role in these diseases and to develop potential therapeutic targets for intervention.