Abcam, ab190310, Anti-ATP5C1 antibody - C-terminal

Size: 200µL
Goat Polyclonal ATP5C1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATP5F1C aa 250 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATP5F1C aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P36542,
Specificity:ab190310 is expected to recognize both reported isoforms (NP_005165.1; NP_001001973.1).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab190310 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ATP5C1 protein also known as ATP synthase subunit gamma plays an important role in cellular energy production. This protein has a mass of approximately 55 kDa. It remains primarily expressed in the mitochondria the powerhouse of cells where it forms a part of the ATP synthase complex. ATP5C1 is essential for ATP synthesis a pivotal process for energy production in cells.
Biological function summary
The ATP5C1 protein is an integral component of the F1 sector of the ATP synthase complex. This complex transduces electrochemical energy into ATP which is the main energy carrier in biological systems. ATP5C1 facilitates rotation of the complex’s central stalk enabling energy conversion. It ensures ATP is produced efficiently supporting various cellular processes. ATP5C1 expression levels affect cellular metabolism and energy homeostasis.
Pathways
ATP5C1 holds an important position within oxidative phosphorylation and the mitochondrial electron transport chain. These pathways are vital for ATP production and involve several proteins and enzymes including NADH dehydrogenase cytochrome c oxidase and other ATP synthase subunits. ATP5C1 interacts with these proteins to sustain the flow of electrons coupling it with proton gradients that drive ATP synthesis.
ATP5C1 mutations or malfunctions link to conditions such as mitochondrial diseases and metabolic disorders. For instance alterations in ATP5C1 can affect ATP synthesis efficiency leading to mitochondrial dysfunction. It also associates with neurodegenerative diseases where inefficient energy production exacerbates neuronal degradation. The protein's dysfunction may involve other proteins like ATP5D a fellow subunit within the ATP synthase complex that collaborates in maintaining ATP production.