Abcam, ab190983, Anti-SCLY antibody - C-terminal

Size: 100µg
Rabbit Polyclonal SCLY antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SCLY aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SCLY aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96I15

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Selenium binding protein 1 often referred to as SCLY participates in the metabolism of selenium an essential trace element in humans. It catalyzes the conversion of selenocysteine to alanine releasing elemental selenium in the process. SCLY has a molecular mass of approximately 62 kDa and is mostly expressed in the liver and kidney tissues indicating its role in metabolic processes in these organs. The activity of SCLY is significant in regulating selenium levels in cells which plays a broader part in protecting cells from oxidative stress.
Biological function summary
The enzyme converts the selenium-containing amino acid selenocysteine which can impact the synthesis of selenoproteins that contain selenium and have various roles including antioxidant functions. SCLY does not work as part of a larger complex but it acts closely with other enzymes involved in selenium metabolism to maintain selenium homeostasis. Maintaining proper selenium balance is important for the antioxidant system in cells which prevents damage caused by oxidative stress.
Pathways
Selenium metabolism involves SCLY as an important enzyme facilitating selenium reuse and selenoprotein synthesis. The metabolic pathway SCLY participates in interacts with the selenoprotein synthesis pathway where other key enzymes such as selenophosphate synthetase 1 are involved. The conversion of dietary selenium compounds to biologically active forms that cells can use relies on this pathway having proper function.
SCLY has links with disorders involving dysregulation of selenium metabolism such as selenium deficiency-related myopathy and liver disorders. Incorrect function of SCLY can impact the levels of selenoproteins connected to such diseases by oxidative damage and cell death. Selenoprotein P is one important protein that connects with SCLY-related impairments because reduced activity of SCLY might result in insufficient synthesis of this protein influential in distributing selenium throughout the body.