Abcam, ab191422, Anti-eIF3g antibody [EPR16146] - N-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal EIF3G antibody. N-terminal. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Rat, Mouse, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16146,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, Flow Cyt (Intra), ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The eIF3g also known as eukaryotic translation initiation factor 3 subunit G is a part of the eIF3 complex. It has a mass of approximately 39 kDa. This protein is expressed in various tissues throughout the body. Mechanically eIF3g participates in the process of initiation during protein synthesis by binding to the small ribosomal subunit and assisting in the recruitment of mRNA and initiator tRNA. This helps in the assembly of the functional ribosome making the translation process efficient.
Biological function summary
EIF3g plays an important role in gene expression by being part of the eIF3 complex which is important for starting translation. As a component of the eIF3 complex eIF3g influences cell growth differentiation and survival by regulating the protein synthesis rates. Researchers have identified that its presence in multiple tissues is essential for the proper functioning of cellular activities indicating its broad importance in maintaining cellular physiology.
Pathways
Experts recognize that eIF3g is integral to the mTOR signaling pathway which governs cell growth in response to nutrient availability. It also plays a significant role in the regulation of the EIF4E activity an important protein in initiating translation. eIF3g influences these pathways by acting together with other subunits of the eIF3 complex and interacting with translation-related proteins.
Disruptions in eIF3g function link to certain cancers such as breast cancer where increased expression levels of eIF3g have been associated with tumor progression. Additionally abnormalities in eIF3g may contribute to neurodegenerative diseases like Alzheimer's disease given its role in protein synthesis and cell survival. In these contexts eIF3g operates alongside proteins like eIF4E and the eIF3 complex to influence disease development and progression.