Abcam, ab191423, Anti-ADCY9/AC9 antibody [EPR16188]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ADCY9/AC9 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16188,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADCY9 also known as AC9 is an enzyme involved in catalyzing the conversion of ATP to cyclic AMP (cAMP) an important secondary messenger in many cellular processes. The protein has a molecular mass of approximately 135 kDa. It is expressed in various tissues with high levels in the brain and immune cells. ADCY9 exhibits unique regulatory properties compared to other members of the adenylyl cyclase family making its study significant for understanding cellular signaling.
Biological function summary
ADCY9 plays a central role in the regulation of cAMP which mediates various physiological responses such as hormone signaling and neurotransmission. ADCY9 does not form part of a multi-protein complex but interacts dynamically with G-protein coupled receptors (GPCRs) and protein kinases that modulate its activity and consequently cAMP levels. These interactions influence cellular responses to external stimuli and ensure precise modulation of intracellular signaling pathways.
Pathways
The regulation of cAMP production by ADCY9 impacts key signaling pathways like the protein kinase A (PKA) pathway and the cyclic AMP response element-binding protein (CREB) pathway. ADCY9 activity affects PKA activation which then phosphorylates various target proteins altering their function and activity. Similarly ADCY9's role in the CREB pathway through cAMP influences gene transcription related to cell survival and differentiation. This places ADCY9 at a significant point in mediating cellular response to hormonal and environmental signals.
Altered ADCY9 expression or function has been linked to conditions such as asthma and heart disease. Variations in ADCY9 can affect cAMP-mediated signaling pathways implicated in the pathophysiology of these diseases. Additionally the interaction between ADCY9 and G-proteins especially in immune cells suggests potential involvement in inflammation-related conditions. Understanding the role of ADCY9 in these disorders can contribute to the development of targeted therapies that modulate its activity providing a potential therapeutic approach.