Abcam, ab192031, Anti-TRPC1 antibody [EPR1417(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRPC1 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1417(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRPC1 also known as the Transient Receptor Potential Channel 1 is a protein that forms ion channels in cell membranes facilitating the movement of calcium ions into cells. TRPC1 has a molecular mass of approximately 89 kDa. It is mainly expressed in the central nervous system such as the brain as well as in tissues like the heart lungs and skeletal muscles. TRPC1 operates as a non-selective cation channel that responds to a variety of stimuli including mechanical thermal and chemical signals.
Biological function summary
TRPC1 plays roles in various cellular functions including cell growth muscle contraction and ion homeostasis. TRPC1 often associates with other TRP channel proteins forming heteromeric complexes that modify its channel properties. Through these complexes TRPC1 contributes to regulating intracellular calcium levels which are important for numerous physiological processes. Its role in maintaining calcium balance highlights its importance in cellular signalling and functional regulation in many cell types.
Pathways
Researchers identify TRPC1 as an essential component of the calcium signalling pathway influencing cellular activities like proliferation and apoptosis. TRPC1 also integrates within the phosphoinositide signalling pathway where it interacts with proteins such as STIM1 and Orai1. These interactions facilitate the entry of calcium ions into the cells important in conditions of calcium store depletion and cellular signalling cascades.
TRPC1 is implicated in cardiovascular diseases and neurodegenerative disorders. Dysregulation of TRPC1 activity leads to altered calcium homoeostasis contributing to the development and progression of conditions like hypertension and Alzheimer's disease. In Alzheimer's interactions between TRPC1 and amyloid precursor protein (APP) may influence neuronal function and survival showcasing its potential as a therapeutic target for research and drug development in these life-impacting conditions.