Abcam, ab192254, Anti-MGST3 antibody [EPR12352]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MGST3 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12352,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MGST3 also known as Microsomal Glutathione S-Transferase 3 is an enzyme involved in the detoxification of electrophilic compounds. It has a molecular mass close to 17 kDa and resides in the endoplasmic reticulum's membrane. MGST3 displays high expression levels in liver and kidney tissues indicating a significant role in these detoxification centers. Together with other microsomal glutathione S-transferases it participates in reducing oxidative stress by conjugating glutathione to a wide range of substrates.
Biological function summary
MGST3 functions as part of a larger enzymatic complex and plays an essential role in xenobiotic metabolism. It protects cells from the toxic effects of various electrophilic compounds aiding the maintenance of cellular health. By facilitating the conversion of lipophilic substances into more water-soluble products MGST3 assists in cellular detoxification processes. This activity underlines the importance of MGST3 in maintaining cellular homeostasis and preventing cellular damage.
Pathways
MGST3 integrates into the glutathione metabolism and arachidonic acid metabolism pathways. In the glutathione pathway MGST3's relationship with glutathione-dependent enzymes supports direct integration into the cell's detoxification processes. Additionally it connects with proteins involved in inflammation and oxidative stress response such as other glutathione S-transferases. By partaking in these pathways MGST3 contributes to the protection against oxidative damage and modulates inflammatory responses.
MGST3 shows relevance to conditions such as drug-induced liver injury and certain types of cancer. Changes in MGST3 expression affect hepatic cellular responses to toxic agents linking it to liver pathologies. In cancer aberrations in MGST3 expression correlate with resistance to chemotherapy making it an area of interest for therapeutic strategies. The enzyme's association with proteins like cytochrome P450 enzymes further implicates its involvement in the metabolic activation of potential carcinogens.