Abcam, ab192265, Anti-NDUFC2 antibody [EPR16499]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NDUFC2 antibody. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16499,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFC2 also known as NADH:ubiquinone oxidoreductase subunit C2 is a protein component of the mitochondrial complex I. It has a molecular mass of approximately 14.4 kDa. This protein is expressed within the mitochondria of various tissues with significant expression observed in high energy-demanding tissues such as the brain heart and muscles. NDUFC2 does not have a catalytic role but contributes to the structural stability of complex I.
Biological function summary
NDUFC2 plays a role as part of the mitochondrial respiratory chain complex I also known as NADH:ubiquinone oxidoreductase. This complex catalyzes the initial step of electron transport helping transfer electrons from NADH to ubiquinone. By contributing to this process NDUFC2 supports ATP production through oxidative phosphorylation which is essential for cellular energy metabolism. Being part of such a complex structure NDUFC2 interacts closely with other subunits of complex I.
Pathways
NDUFC2 involves itself in the oxidative phosphorylation and the citric acid cycle. These pathways are vital for energy conversion and metabolic processes. Within oxidative phosphorylation NDUFC2 relates to proteins such as NDUFB10 and NDUFS1 which are additional components of complex I. This protein along with its complex counterparts ensures efficient electron transport and ATP synthesis.
NDUFC2 associates with mitochondrial disorders that stem from complex I deficiencies. Such diseases include Leigh syndrome a severe neurological disorder and mitochondrial encephalomyopathy. Interactions with other complex I proteins like NDUFS3 and NDUFV1 highlight the role of NDUFC2 in these conditions. Mutations or deficiencies in NDUFC2 can impact cellular energy metabolism contributing to the pathophysiology of these disorders.