Abcam, ab192582, Anti-MLL5 antibody

Size: 100µg
Rabbit Polyclonal MLL5 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KMT2E.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human KMT2E.Q8IZD2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab192582 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)., Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MLL5 also known as KMT2E is a member of the mixed-lineage leukemia (MLL) family of histone methyltransferases and it is a protein with a mass of approximately 210 kDa. The protein is expressed in various human tissues with higher levels noted in the brain and testis. MLL5 functions mechanically by adding methyl groups to histone H3 at lysine 4 (H3K4) which plays a significant role in chromatin remodeling and regulating gene expression.
Biological function summary
MLL5 participates in the modulation of gene transcription influencing cell cycle progression and differentiation. This protein associates with other proteins to form multi-protein complexes that regulate epigenetic modifications and influence gene expression patterns necessary for development and proliferation. MLL5 also interacts with various transcription factors contributing to cellular responses during immune system development and function.
Pathways
The protein MLL5 plays a critical role in various signaling pathways including the Wnt signaling and the DNA repair pathways. It associates with proteins like β-catenin in the Wnt pathway and works with the protein P53 in DNA damage response and repair. These interactions help maintain genomic stability and proper cellular responses to developmental cues and stress.
Alterations in MLL5 expression impact conditions like acute myeloid leukemia (AML) and neurodegenerative diseases. In AML MLL5 interactions with other regulatory proteins like AML1/ETO influence cell growth and differentiation pathways contributing to disease pathology. In neurodegenerative conditions MLL5 dysregulation affects neuronal survival and function potentially through pathways involving tau proteins. Understanding these connections helps develop therapeutic strategies for these disorders.