Abcam, ab192615, Anti-LIPH antibody [EP12065]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LIPH antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP12065,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
The production method has been switched from hybridoma to recombinant on 06th June 2025.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LIPH protein also known as lipase member H functions mechanically as a phosphatidic acid phosphatase enzyme. It specifically hydrolyzes phosphatidic acid to produce lysophosphatidic acid (LPA) and free fatty acid. This protein has an approximate mass of 54 kDa. The LIPH gene expresses primarily in the scalp but also in other skin regions where it plays a role in hair and skin biology.
Biological function summary
LIPH contributes to the production of lysophosphatidic acid a signaling lipid that influences various biological processes. It is not part of a larger protein complex but operates independently. LIPH activity leads to the modification of cellular environments affecting processes like cell proliferation and migration. The protein impacts structures related to skin and hair by regulating the availability of active signaling lipids.
Pathways
LIPH's function connects to the G-protein-coupled receptor (GPCR) signaling pathway and the metabolic pathway of lipid remodeling. Both pathways involve several biomolecular interactions including those with lysophosphatidic acid receptors which signal downstream biological effects. Moreover LIPH interacts with pathways involving lipids that influence cell dynamics linking it closely to proteins like autotaxin (ENPP2) which also manages LPA levels.
Anomalies in LIPH activity have associations with hair loss disorders such as hypotrichosis and woolly hair syndrome. Genetic mutations disrupting LIPH function lead to improper LPA production affecting hair follicle development. Additionally LIPH links to alopecia-related proteins like lysophosphatidic acid receptors which further ties its function to regulatory networks important for maintaining normal hair growth and scalp health.