Abcam, ab192785, Anti-AKR1C1 antibody

Size: 50µL
Rabbit Polyclonal AKR1C1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AKR1C1 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AKR1C1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q04828,
Specificity:This antibody cross-reacts with AKR1C2.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.00038% 5-chloro-2-methyl-4-isothiazolin-3-one, 0.00038% 2-methyl-4-isothiazolin-3-one, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AKR1C1 also known as Aldo-Keto Reductase Family 1 Member C1 is an enzyme that performs functions related to the reduction of steroids prostaglandins and xenobiotics. It has a molecular mass of approximately 37 kDa. AKR1C1 is expressed in various tissues including the liver lungs and prostate. It exhibits significant activity in hormone-sensitive tissues reflecting its role in steroid metabolism.
Biological function summary
AKR1C1 participates in the conversion of ketosteroids to hydroxysteroids important for the regulation of steroid hormone activity. As part of the aldo-keto reductase (AKR) superfamily it works alongside similar enzymes such as AKR1C2 and AKR1C3. Its activity in converting active androgens into their less active forms influences processes like testosterone metabolism playing a role in modulating cellular responses to hormones.
Pathways
AKR1C1 is heavily involved in the steroid hormone biosynthesis and prostaglandin metabolism pathways. This enzyme catalyzes reductions that are essential in maintaining homeostasis of hormone levels. It is functionally related to proteins such as 5α-reductase in steroid biosynthesis. Within these pathways AKR1C1's regulation of androgens directly influences processes of cellular proliferation and differentiation.
AKR1C1 has a connection to hormone-dependent cancers such as prostate cancer due to its role in steroid metabolism. The enzyme's conversion of potent androgens impacts progression and treatment outcomes in such cancers. Additionally AKR1C1 relates to disorders of sex development as imbalances in androgen regulation can lead to abnormal sexual differentiation. In these contexts AKR1C1 potentially cooperates with proteins like cytochrome P450 enzymes impacting disease progression and therapeutic targets.