Abcam, ab192879, Anti-STRAD antibody [EPR15603]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal STRAD antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Rat samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15603,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Based on the sequence analysis, ab192879 recognizes six isoforms with the predicted MWs of 48KDa, 39KDa, 44KDa, 33KDa, 42KDa and 35KDa, respectively.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The STE20-related adaptor (STRAD) is a pseudokinase that functions in cellular processes by regulating the LKB1 kinase activity. Also known as STRADA its molecular mass varies but it typically weighs around 50 kDa. STRAD is expressed in various tissues including the brain liver and muscle. This wide expression suggests it plays multiple roles in cellular function.
Biological function summary
STRAD interacts with the serine/threonine-protein kinase LKB1 to promote its catalytic activity. It forms a complex with LKB1 and MO25 which stabilizes LKB1 in an active conformation. This complex plays an important role in regulating cellular energy balance and cell polarity. STRAD’s interaction is essential for localizing LKB1 to the cytoplasm where LKB1 exerts its function.
Pathways
STRAD plays a significant role in the AMP-activated protein kinase (AMPK) pathway which is important for maintaining energy homeostasis. It helps activate AMPK through its relationship with LKB1. STRAD is also involved in the PI3K/AKT pathway which affects cell growth and survival demonstrating its impact on critical signaling processes. The interplay of STRAD with these pathways involves interactions with related proteins such as AMPK subunits and AKT.
Malfunction or mutation of the STRAD protein has been implicated in Peutz-Jeghers syndrome a disorder characterized by gastrointestinal polyps and an increased cancer risk. This association is largely due to its interaction with LKB1 mutations of which are known to drive the disease. STRAD alterations have also been associated with certain forms of epilepsy given its role in neuron function and brain expression. The involvement in these health conditions underlines the importance of STRAD in human health.