Abcam, ab194554, Anti-SelI antibody

Size: 50µL
Mouse Polyclonal SelI antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SELENOI aa 1-50.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SELENOI aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9C0D9

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SelI also known as selenoprotein I plays an important role in synthesizing selenocysteine a rare amino acid with antioxidant functions. It has a molecular mass of around 65 kDa. SelI is expressed in a wide range of tissues with notable levels detected in the liver brain and heart. This distribution suggests its involvement in several essential cellular processes across different organ systems.
Biological function summary
SelI contributes by supporting selenoprotein biosynthesis and function underpinning cellular antioxidative processes and redox homeostasis. As a part of a larger multi-protein complex SelI ensures the efficient incorporation of selenocysteine into proteins which is essential for the function of many enzymes. Its integration into these complexes highlights its importance in maintaining cellular health and preventing oxidative damage.
Pathways
SelI stands out in the selenoprotein synthesis pathway. This pathway involves the interplay of other proteins including SECIS-binding protein 2 (SBP2) and selenophosphate synthetase 2. It also intersects with the glutathione metabolic pathway linking SelI to cellular detoxification systems. These connections allow SelI to play a part in controlling oxidative stress through well-known antioxidant mechanisms.
SelI has significant connections to neurodegenerative diseases such as Alzheimer's disease and liver disorders. Its relationship with Alzheimer’s is through its role in managing oxidative stress which has implications in the neurodegeneration seen in this disorder. Meanwhile in liver disorders SelI's function ties to its selenoprotein-related antioxidative capabilities working with proteins like glutathione peroxidase to guard against liver damage. These associations mark SelI as an important focus of study in understanding and potentially managing these conditions.