Abcam, ab194749, Anti-PKC beta 1 + PKC beta 2 (phospho T641) antibody

Size: 100µL
Rabbit Polyclonal KPCB phospho T641 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PRKCB phospho T641.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PRKCB phospho T641. The exact immunogen used to generate this antibody is proprietary information.P05771

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PKC beta 1 and PKC beta 2 collectively known as protein kinase C beta isoforms are serine/threonine kinases that belong to the protein kinase C (PKC) family. These isoforms are encoded by the PRKCB gene and play an important role in intracellular signaling. PKC beta 1 and beta 2 weigh approximately 78 kDa and are expressed in various tissues including brain heart and hematopoietic cells. These proteins require diacylglycerol (DAG) and phosphatidylserine for activation linking them to processes initiated by calcium and lipid signaling.
Biological function summary
PKC beta 1 and PKC beta 2 are essential for the regulation of cellular functions such as proliferation differentiation and apoptosis. They are part of larger signaling complexes within the cell interacting with other proteins to mediate their effects. These kinases modulate signal transduction pathways that influence gene expression and cytoskeletal reorganization. They are also involved in immune response regulation impacting B-cell and T-cell receptor signaling.
Pathways
PKC beta isoforms are integral to the PI3K/AKT and NF-κB signaling pathways. In the PI3K/AKT pathway they help coordinate cell survival and growth alongside other proteins like AKT and mTOR. In the NF-κB pathway PKC beta isoforms assist in controlling inflammation and immune responses with proteins such as IKK and NF-κB playing connected roles. These pathways highlight the importance of PKC beta isoforms in cell signaling networks and highlight their influential role in maintaining cellular homeostasis.
PKC beta isoforms are implicated in the development of diabetes mellitus and certain cancers such as B-cell lymphoma. In diabetes mellitus PKC beta signaling affects insulin resistance and endothelial function connecting to proteins like insulin receptor substrates. In B-cell lymphoma aberrant activation of PKC beta isoforms leads to uncontrolled cell proliferation involving proteins like BCL2. These associations highlight the potential for targeting PKC beta isoforms in therapeutic strategies for these diseases.