Abcam, ab194906, HRP Anti-PKC beta 2 antibody [Y125]

Size: 100µL
Rabbit Recombinant Monoclonal KPCB antibody - conjugated to HRP. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:Y125,
Isotype:IgG,
Conjugation:HRP,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Epitope:ab32026 reacts with an epitope located in the region near the C terminus of PKC beta 2.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.1% Proclin 300 SolutionConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein kinase C beta 2 also known as PKC beta 2 or PRKCB is an important isoform of the PKC family with a molecular weight of 79 kDa. PKC proteins are a group of serine/threonine kinases involved in various cellular processes. PKC beta 2 expresses in tissues like the spleen lymph nodes and other immune-related tissues. The protein plays a significant role in immune responses and its expression is regulated by various signaling molecules.
Biological function summary
PKC beta 2 acts as an important regulator in the immune system by modulating immune cell activation and proliferation. It functions as part of the PKC protein complex which interacts with lipids and calcium as cofactors. This protein has critical influence on processes such as B-cell activation and phagocyte response. It also regulates several transcription factors impacting gene expression critical for the immune system.
Pathways
PKC beta 2 integrates into multiple signaling pathways including the NF-kB and MAPK pathways. These pathways are essential for transmitting signals from the cell surface to the nucleus affecting gene expression and cell function. PKC beta 2 directly influences protein interactions within these pathways such as with other PKC family members and other proteins like IKK which is critical in the NF-kB signaling pathway.
PKC beta 2 is significantly connected to certain cancers and autoimmune conditions. Aberrant PKC beta 2 activity is linked to chronic lymphocytic leukemia where it affects the survival and proliferation of B cells. It is also involved in diabetic nephropathy contributing to kidney damage through excessive signaling. In these conditions PKC beta 2 interacts with proteins like Bcl-2 in cancer and TGF-beta in diabetic nephropathy influencing the disease courses and potentially serving as targets for therapeutic interventions.