Abcam, ab195207, Anti-pan-myc antibody [EPR18863]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal C-Myc/MYC antibody. Suitable for ChIC/CUT&RUN-seq, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18863,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ChIC/CUT&RUN-seq, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan-MYC refers to a group of transcription factors in the MYC family primarily comprising c-Myc N-Myc and L-Myc with c-Myc weighing around 49 kDa. MYC proteins are nuclear phosphoproteins that regulate gene expression. MYC proteins express in various tissues including embryonic stem cells and proliferating cells and they are known for their involvement in cell cycle progression apoptosis and cellular transformation.
Biological function summary
MYC proteins perform an important role in the regulation of transcription by binding to DNA at E-box sequences. They function as part of the MYC/MAX/MAD network a transcriptional complex with MAX as the obligate partner. This network influences genes involved in cellular growth metabolism and differentiation. Deregulation of MYC proteins affects many cellular processes and can influence normal physiology.
Pathways
The MYC proteins are central to the regulation of the cell cycle and Wnt signaling pathways. In the PI3K/Akt signaling MYC interacts with other signaling molecules to control cell growth and survival. The E-box binding allows MYC to regulate multiple downstream targets including cyclins and growth factor receptors. MYC's ability to form a complex with MAX also interlinks it with other survival and proliferation pathways.
Aberrant MYC expression correlates with various cancers such as Burkitt's lymphoma and neuroblastoma. Overexpression of MYC often results from chromosomal translocations or gene amplifications in these malignancies. MYC's connection with the BCL2 protein leads to the disruption of apoptosis promoting oncogenic transformation. Control of MYC expression and function remains a critical focus in cancer research due to its role in tumor development.