Abcam, ab196503, Anti-GSTM2 antibody

Size: 100µL
Rabbit Polyclonal GSTM2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GSTM2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GSTM2.P28161

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GSTM2 or Glutathione S-transferase Mu 2 is an enzyme with a mass of approximately 25 kDa. This protein functions mechanically by catalyzing the conjugation of glutathione to various hydrophobic and electrophilic compounds which enhances their solubility and facilitates their excretion. The enzyme is expressed in many tissues with high levels in the liver brain and lungs contributing to detoxification processes within these organs.
Biological function summary
The enzyme GSTM2 plays a critical role in cellular protection against oxidative stress and toxic compounds. It functions as part of a complex detoxification system interacting with reactive intermediates to prevent cellular damage. GSTM2 acts synergistically with other enzymes in the glutathione-dependent pathways to maintain cellular integrity and prevent damage from free radicals and peroxides.
Pathways
GSTM2 is heavily involved in cellular detoxification pathways and the metabolism of xenobiotics. It connects to the glutathione metabolism pathway working alongside proteins such as GSTP1 and GSTA1. These pathways are essential for protecting cells from oxidative damage and managing cellular responses to stress making GSTM2 an important player in maintaining cellular homeostasis.
GSTM2 has implications in cancer and asthma. Altered expression levels and polymorphisms in the GSTM2 gene can associate with increased cancer risk due to the impaired ability to detoxify carcinogens. In asthma changes in GSTM2 expression may contribute to an improper response to oxidative stress and inflammation. Related proteins like GSTP1 also share involvement in these conditions underlining the significance of the glutathione S-transferase family in disease susceptibility.