Abcam, ab196631, Anti-PDZK3/Pin1 antibody

Size: 100µL
Rabbit Polyclonal PDZK3/Pin1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PDZD2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PDZD2. The exact immunogen used to generate this antibody is proprietary information.O15018

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDZK3 also known as Pin1 is a peptidyl-prolyl cis-trans isomerase that weighs approximately 18 kDa. It modifies the conformation of phosphorylated serine/threonine-proline motifs influencing protein function and stability. PDZK3 is expressed in many tissues including the brain heart and lungs. It plays a significant role in cellular processes by altering protein-protein interactions through its isomerase activity.
Biological function summary
PDZK3 performs a critical role in regulating cell cycle progression and growth through its modulation of protein folding and conformation changes. It is a part of a complex functioning with other proteins to stabilize and regulate substrates such as Cdc25C a phosphatase and cyclin-dependent kinases. These interactions facilitate transitions between cell cycle phases and support cellular response to various stimuli.
Pathways
PDZK3 directly participates in signal transduction processes particularly the MAPK/ERK pathway and the Wnt signaling pathway. In the MAPK/ERK pathway PDZK3 interacts with proteins such as Raf-1 and MEK1 to impact cell proliferation and differentiation. In the Wnt signaling pathway PDZK3 connects with beta-catenin contributing to regulation of gene expression and maintenance of cellular functions.
PDZK3's dysregulation correlates with cancer and Alzheimer's disease. PDZK3 overexpression or malfunction may lead to unchecked cell division and tumorigenesis linking it with oncogenic proteins such as c-Myc. In Alzheimer's disease PDZK3 affects tau phosphorylation connecting with tau proteins which can cause tau tangles contributing to cognitive decline. Understanding PDZK3's involvement offers insights into therapeutic targets for these conditions.