Abcam, ab196651, Anti-Scavenging Receptor SRB2 antibody [EPR12081] - C-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LIMPII antibody. C-terminal. Suitable for WB, Flow Cyt (Intra), IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12081,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Scavenging receptor SRB2 also known as CD36 is a transmembrane glycoprotein with a molecular mass of approximately 88 kDa. This receptor is widely expressed in various tissues including adipose tissue heart skeletal muscle and certain endothelial cells. It functions as a scavenger receptor by mediating the uptake of oxidized low-density lipoproteins (oxLDL) fatty acids and other ligands. CD36 is involved in several mechanisms such as lipid metabolism inflammation and cell adhesion due to its interaction with a variety of ligands and its presence on the cell surface.
Biological function summary
Scavenger receptor class B type 2 plays a significant role in the transport and metabolism of lipids. CD36 is not part of a higher-order complex but associates with integrins to mediate cell adhesion and signaling. It aids in the cellular uptake of long-chain fatty acids which is important for energy homeostasis. It also participates in the immune response by recognizing pathogens and facilitating their clearance. The receptor's ability to bind a diverse range of ligands marks it as an important player in maintaining cellular lipid balance and immune functions.
Pathways
Scavenger receptor SRB2 integrates into the fatty acid metabolism and inflammatory pathways. Within the fatty acid metabolism pathway it facilitates the uptake of fatty acids into cells working closely alongside proteins like FABP (fatty acid-binding proteins). In the context of inflammatory pathways SRB2 participates in the recognition and clearance of oxLDL influencing the activity of proteins such as TLR4 (Toll-like receptor 4) which are involved in the immune response. Through these pathways CD36 modulates critical cellular processes including lipid storage oxidation and inflammatory responses.
Scavenger receptor SRB2 has significant connections to atherosclerosis and type 2 diabetes. In atherosclerosis the receptor contributes to plaque formation by mediating the uptake of oxLDL a process linked with lipoprotein metabolism. Additionally CD36's role in fatty acid uptake and utilization associates it with insulin resistance making it relevant in the pathophysiology of type 2 diabetes. Interactions with other proteins such as PPARγ (peroxisome proliferator-activated receptor gamma) in these conditions highlight the receptor's part in lipid-induced inflammation and metabolic dysfunctions.