Abcam, ab197013, Anti-ABCD1/ALD antibody [EPR15929]

Size: 100µL / 1mL
Anti-ABCD1/ALD antibody [EPR15929] (ab197013) is a rabbit monoclonal antibody detecting ABCD1/ALD in Western Blot, Flow Cytometry (Intra), Flow Cytometry, ICC/IF . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15929,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-ABCD1/ALD antibody [EPR15929] (ab197013) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of ABCD1/ALD?
Anti-ABCD1/ALD [EPR15929] (ab197013) specifically detects a band for ABCD1/ALD (UniProt: P33897) at a molecular weight of 83kDa.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR15929] also available for your convenience: ab197013, Alexa Fluor® 647 -
ab225409
, Alexa Fluor® 488 -
ab225410
, Carrier free -
ab238989
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABCD1 also known as the ABCD1 protein or ALD protein is encoded by the ABCD1 gene and belongs to the ATP-binding cassette (ABC) transporter family. It functions mechanically by transporting very long-chain fatty acids (VLCFAs) into peroxisomes where they can be metabolized. ABCD1 has a mass of approximately 80 kDa. Expression of ABCD1 is significant in tissues such as the liver adrenal glands and brain where it plays a role in lipid metabolism and cellular detoxification processes.
Biological function summary
ABCD1 contributes to the maintenance of normal fatty acid levels within cells. It is not known as part of a larger protein complex but it cooperates closely with other peroxisomal enzymes to facilitate the beta-oxidation of VLCFAs. This action ensures the breakdown of toxic compounds and has a significant role in maintaining cellular homeostasis. The proper function of ABCD1 is essential for preventing the accumulation of VLCFAs which can affect cellular function and viability.
Pathways
ABCD1 is integral to the metabolic pathway of peroxisomal beta-oxidation. This pathway is important for the degradation of excess VLCFAs which are otherwise difficult to break down in mitochondria. ABCD1 works in concert with related proteins such as ABCD2 and ABCD3 playing differentiated yet sometimes overlapping roles in lipid transport and metabolism. This cooperation is important for maintaining normal cellular metabolism and preventing lipid accumulation.
Defects in ABCD1 are directly associated with X-linked adrenoleukodystrophy (X-ALD) a neurodegenerative disorder characterized by the accumulation of VLCFAs in tissues. This condition leads to severe neurological impairment due to the toxic buildup of these lipids which disrupts normal brain function. Additionally the ABCD1 protein's dysfunction can indirectly affect the function of other proteins involved in lipid metabolism potentially exacerbating conditions related to peroxisomal disorders.