Abcam, ab197188, Anti-ITIH3 antibody

Size: 100µg
Rabbit Polyclonal ITIH3 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inter-alpha-trypsin inhibitor heavy chain H3 aa 350-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Inter-alpha-trypsin inhibitor heavy chain H3 aa 350-550. The exact immunogen used to generate this antibody is proprietary information.Q06033

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Inter-Alpha-Trypsin Inhibitor Heavy Chain H3 (ITIH3) is a protein composed of approximately 96 kDa. Researchers commonly refer to it by its abbreviation ITIH3. It is part of the inter-alpha-trypsin inhibitors family which plays roles in multiple biological processes. ITIH3 expresses mainly in the liver but also shows its presence in other tissues and bodily fluids. This protein has a structural component that stabilizes the extracellular matrix by covalently binding with hyaluronan a necessary process for maintaining tissue integrity.
Biological function summary
ITIH3 functions in the extracellular matrix and as a stabilizer in tissue architecture. It forms a multi-protein complex with other proteins in its family such as ITIH1 and ITIH2. This complex facilitates the inhibition of extracellular proteases and contributes to hyaluronic acid stabilization. The activity of ITIH3 is significant for physiological processes that require a stable extracellular matrix. Protective roles like wound healing and inflammatory response modulation benefit from ITIH3's presence in tissues.
Pathways
ITIH3 interacts closely with processes involved in cell migration and inflammation. Specifically it takes part in the hyaluronan metabolic pathway alongside other proteins like TSG-6 which also aid in stabilizing the extracellular matrix. ITIH3 influences cellular signaling pathways that affect tissue responses to stress and injury. Understanding how ITIH3 functions within these pathways reveals insights into its roles in tissue repair and cellular integrity.
Researchers linked ITIH3 to neuropsychiatric disorders like schizophrenia and bipolar disorder. Genome-wide association studies have identified connections between ITIH3 and these conditions highlighting its significance in disease biology. Studies revealed links between ITIH3 and other proteins like ITIH4 in schizophrenia-related pathways. ITIH3's involvement in maintaining tissue stability and regulating inflammation might influence its connection to these disorders. This information suggests that ITIH3 potentially serves as a biomarker or therapeutic target in relevant disease contexts.