Abcam, ab197932, Anti-EPDR1 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal EPDR1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to EPDR1, fused to EPDR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Fusion protein corresponding to EPDR1, fused to EPDR1. The exact immunogen used to generate this antibody is proprietary information.Q9UM22

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPDR1 also known as Ependymin-Related 1 is a protein involved in cellular adhesion and signaling. It has an approximate molecular mass of 55 kDa. EPDR1 is expressed in various tissues with significant levels found in the brain and also in some cancerous tissues. The protein plays a role in cellular interaction by mediating cell-cell and cell-matrix adhesion contributing to cellular cohesion and integrity.
Biological function summary
EPDR1 functions in processes of cell adhesion and immune response modulation. It may form complexes with other proteins that help regulate the structural organization of cells within tissue matrices. This modulation is essential for the repair and maintenance of tissue architecture actively influencing how cells respond to environmental changes.
Pathways
EPDR1 is significant in the ECM-receptor interaction pathway and plays a role in cell communication pathways. It interacts with other proteins like integrins which are important in mediating outside-in signaling processes. This interaction facilitates various downstream signaling events that are necessary for maintaining cell and tissue structure.
EPDR1 has been associated with cancer and neurodegenerative diseases. It may influence cancer progression through its impact on cell adhesion potentially affecting metastasis by altering cell motility and detachment. In neurological contexts the relationship with neurodegenerative diseases links to proteins like amyloid-beta where modulation by EPDR1 can affect disease progression by influencing cellular adhesion properties in neural tissues.