Abcam, ab198215, Anti-GLIPR1 antibody

Size: 100µL
Rabbit Polyclonal GLIPR1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GLIPR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GLIPR1. The exact immunogen used to generate this antibody is proprietary information.P48060

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLIPR1 also known as Glioma Pathogenesis Related Protein 1 functions mechanically as a protein involved in cellular processes. Its mass is approximately 39 kDa. Researchers have found it expressed in various tissues such as the kidney lung prostate and brain. The protein occurs at higher levels in certain tumor cells suggesting a significant role in cancer biology. Different studies also refer to this protein as GLIPR1L1 or CRISP4 highlighting its complexity.
Biological function summary
GLIPR1 plays an important role in regulating the immune response and apoptosis affecting cellular survival and death. It can influence cell adhesion and motility essential for normal tissue maintenance and response to injury. GLIPR1 acts as part of larger cellular complexes that modulate critical cellular functions. It shows interaction with the tumor suppressor p53 further emphasizing its role in tumorigenesis and cell cycle regulation.
Pathways
GLIPR1 integrates into the p53 signaling and apoptosis pathways affecting how cells respond to stress and damage. The protein interacts with several components including p53 itself to mediate cellular apoptosis. GLIPR1 also participates in mechanisms that regulate inflammation possibly linking it to immune system pathways alongside proteins like NF-kB which plays a role in inflammatory responses.
Researchers have associated GLIPR1 with cancers notably prostate and glioblastoma. The protein's abnormal expression correlates with tumor progression and patient prognosis. GLIPR1 also connects to inflammatory disorders due to its role in modulating immune responses. Its interaction with p53 highlights its significance in cancer pathogenesis making it a target for potential therapeutic strategies.