Abcam, ab198225, Anti-GNG2 antibody

Size: 100µL
Rabbit Polyclonal GNG2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNG2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GNG2.P59768

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNG2 also known as G-protein subunit gamma-2 is a small protein with a mass of approximately 8.5 kDa. It is a component of the heterotrimeric G-protein complex playing an essential role in signal transduction. GNG2 is expressed in various tissues including the brain heart and epithelial tissues. Its expression indicates a role in diverse cellular functions through its interaction with other G-protein subunits.
Biological function summary
GNG2 forms part of the G-protein complex involved in transmitting signals from G-protein-coupled receptors (GPCRs) on the cell membrane to internal signaling pathways. This protein interacts with alpha and beta subunits to modulate downstream signaling cascades. The G-protein complex including GNG2 is essential for the activation of cellular responses to hormones neurotransmitters and environmental stimuli. It plays a significant role in regulating the activity of various effectors including adenylyl cyclase and phospholipase C.
Pathways
GNG2 is directly involved in GPCR signaling pathways including the MAPK/ERK pathway and the PI3K/AKT pathway. These pathways are important for cell proliferation differentiation and survival. GNG2 interacts with other proteins like GNAS and PLCβ in these pathways contributing to the regulation of cellular responses and maintaining homeostasis. Its function in these pathways highlights its importance in coordinating complex cellular activities.
GNG2 has associations with cancer and cardiovascular diseases. Its interaction with proteins like RAS and PI3K suggests a role in tumorigenesis and cancer progression where dysregulated GPCR signaling could lead to abnormal cell growth. GNG2 also connects with proteins involved in cardiovascular functions such as those within the PI3K/AKT pathway indicating a potential link to cardiac disorders. Understanding GNG2's role in these diseases may offer insights into therapeutic targets for intervention.