Abcam, ab198272, Anti-MCT2 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal MCT2 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC16A7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC16A7. The exact immunogen used to generate this antibody is proprietary information.O60669

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MCT2 also known as monocarboxylate transporter 2 or SLC16A7 plays a mechanical role in the transport of monocarboxylates such as lactate pyruvate and ketone bodies across cell membranes. With a molecular mass of approximately 53 kDa MCT2 is expressed in various tissues including the brain liver and skeletal muscles. It is in the plasma membrane where it facilitates the rapid exchange of substrates important for energy metabolism in cells.
Biological function summary
MCT2 facilitates the movement of lactate and other monocarboxylates impacting cellular energy production and homeostasis. It may associate with chaperone proteins like basigin or CD147 which assist in its proper localization in the membrane. This transporter plays a role in metabolic communication between cells reflecting its importance in maintaining high-energy demands especially in neurons and muscle cells.
Pathways
MCT2 has a vital function in glycolysis and oxidative phosphorylation by mediating lactate transport. It participates in the Cori cycle which integrates with glucose metabolism and works alongside lactate dehydrogenase (LDH) to shuttle lactate for gluconeogenesis in the liver. MCT2's operation affects cellular energy balance and tissue responses to metabolic fluctuations.
MCT2 has connections to cancer and neurological disorders such as epilepsy. In cancer altered MCT2 expression affects tumor metabolism and progression interacting with hypoxia-inducible factor-1 (HIF-1) which controls glycolytic enzymes. In neurological conditions deficient or excessive lactate transport by MCT2 could impact neuronal excitability and energy balance potentially linking it to disease-related proteins like glutamate receptors.