Abcam, ab198283, Anti-FOXF2 antibody

Size: 100µL
Rabbit Polyclonal FOXF2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human FOXF2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FOXF2. The exact immunogen used to generate this antibody is proprietary information.Q12947

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXF2 also known as Forkhead box F2 is a transcription factor involved in various developmental processes. It belongs to the FOX protein family characterized by a distinct DNA-binding forkhead domain. FOXF2 has a molecular mass of approximately 44 kDa. This protein finds expression mainly in tissues like lung kidney and heart playing roles in organ development and function. Scientists often study FOXF2 for its ability to regulate gene expression during embryonic development and repair processes.
Biological function summary
Forkhead box F2 functions involve gene regulation critical for cellular differentiation and organ development. FOXF2 operates as part of a larger network involving several transcription factors and does not generally work as an isolated entity. In tissues where it expresses FOXF2 helps maintain structural integrity and cell type-specific functions contributing to proper organogenesis. Studies highlight its role in mesodermal tissue development where FOXF2 participates in the regulation of epithelial-mesenchymal interactions.
Pathways
FOXF2 plays an important role in the TGF-beta signaling and Wnt signaling pathways which greatly affect cell proliferation differentiation and carcinogenesis. In the TGF-beta signaling pathway FOXF2 interacts with proteins like SMAD4 to drive transcriptional responses necessary for developmental processes. In the context of the Wnt signaling pathway FOXF2 influences cellular proliferation and differentiation indirectly although evidence links it with this pathway through certain downstream effects and interactions involving proteins like beta-catenin.
FOXF2 has shown a connection to breast cancer and congenital cardiac defects. Dysfunction or altered expression of FOXF2 can contribute to developmental anomalies and has been linked to tumorigenesis particularly influencing breast cancer progression through interactions with the TGF-beta pathway. Furthermore FOXF2 associates with proteins such as periostin in influencing breast cancer metastasis. Abnormal FOXF2 expression may also contribute to heart defects by disrupting normal signaling pathways essential for cardiovascular development.