Abcam, ab198290, Anti-PPP2R5E antibody [EPR17146]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal 2A5E antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17146,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PPP2R5E also known as B56 epsilon is a regulatory subunit of protein phosphatase 2A (PP2A). It has an approximate mass of 72 kDa. PPP2R5E expresses across various tissues including the brain heart and skeletal muscle. The subunit associates with the core PP2A enzyme influencing substrate specificity and activity of PP2A holoenzyme.
Biological function summary
PPP2R5E plays a role in regulating cell growth and division. It is a part of the PP2A holoenzyme complex acting as a critical modulatory component. By associating with the PP2A core enzyme PPP2R5E contributes to the dephosphorylation process of many substrates. These substrates are vital for maintaining cellular functions such as signal transduction and cell cycle progression.
Pathways
PPP2R5E takes part in cell signaling and apoptotic pathways. It has substantial involvement in the MAPK signaling pathway where it modulates the activity of related kinases. PPP2R5E interacts with proteins like RAF1 influencing the pathway's function. Additionally it also participates in the Wnt signaling pathway where its regulatory role impacts cellular differentiation and proliferation.
PPP2R5E shows links to cancer and neurodegenerative diseases. Alterations in its expression or function may lead to oncogenesis due to its role in controlling cell proliferation signals. The dysregulation of PP2A activity potentially through PPP2R5E has associations with Alzheimer’s disease. In cancer PPP2R5E interacts with proteins such as c-Myc which contributes to tumorigenesis and progression.