Abcam, ab198712, Anti-Galactoside 2-alpha-L-fucosyltransferase 1 antibody

Size: 100µL
Rabbit Polyclonal Galactoside 2-alpha-L-fucosyltransferase 1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FUT1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FUT1. The exact immunogen used to generate this antibody is proprietary information.P19526,
Specificity:May cross react with FUT2.

Product details:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Galactoside 2-alpha-L-fucosyltransferase 1 also known as FUT1 is an enzyme that plays a role in the addition of fucose a hexose sugar to galactose residues on glycoconjugates. FUT1 has a molecular weight of approximately 44 kDa. It is expressed in various tissues including the liver gastrointestinal tract and endothelial cells indicating a broad functional presence. By transferring fucose in an alpha-12 linkage FUT1 modifies glycoproteins and glycolipids impacting their structure and function.
Biological function summary
FUT1 contributes to the synthesis of H antigen a precursor for ABO blood group antigens by adding fucose to galactoside. It does not usually function as part of a larger protein complex but can have interaction with other components of the glycosylation machinery to ensure proper cellular glycan composition. The action of FUT1 influences cell-cell adhesion signaling and the immune response by shaping cell surface glycan landscapes.
Pathways
FUT1 participates in glycosylation pathways critical for proper cellular recognition and signaling. It plays an important role in the glycosphingolipid biosynthesis pathway that involves the synthesis of the H antigen important for blood group antigen formation. In these pathways FUT1 works in conjunction with other fucosyltransferase family members like FUT2 jointly contributing to the overall diversity of glycan structures found on the cell surface.
FUT1 has implications in several conditions due to its role in glycosylation. Abnormal expression levels can influence the development of certain cancers where altered glycosylation patterns contribute to cell metastasis and immune evasion. Additionally FUT1 modifications could affect the susceptibility to infections by pathogens that recognize specific glycan structures. FUT1's role in cancer is often examined in connection with proteins related to cell adhesion and the immune system such as selectins which interact with glycan structures for cell trafficking and immune response regulation.