Abcam, ab198815, Anti-MMP20 antibody

Size: 100µL
Rabbit Polyclonal MMP20 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MMP20.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MMP20. The exact immunogen used to generate this antibody is proprietary information.O60882

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MMP20 also known as Enamelysin is a member of the matrix metalloproteinase (MMP) family. This enzyme has a molecular mass of approximately 54 kDa. MMP20 is mainly expressed in the dental enamel but researchers have also observed its expression in other tissues like the epithelial and mesenchymal cells of the developing tooth. The enzyme plays a role in the breakdown of extracellular matrix components specifically during the formation of tooth enamel where it processes the nascent enamel matrix proteins.
Biological function summary
MMP20 participates in enamel development and maturation. This enzyme cleaves amelogenin an important protein in the enamel matrix to aid in proper enamel mineralization. MMP20 does not function alone; it exists as part of the complex processes necessary for the tooth structure formation. By regulating protein processing MMP20 ensures the replacement of organic matrix with inorganic mineral important for the hardness of enamel.
Pathways
The involvement of MMP20 is critical in the enamel mineralization pathway and intralays network of amelogenesis. It connects with other proteins like ameloblastin and enamelin which collaborate in enamel formation. MMP20 affects these pathways by enabling the proteolytic processing of enamel-specific proteins supporting the structural changes and mineral deposition essential for hard enamel formation.
The role of MMP20 appears significant in amelogenesis imperfecta a genetic condition that affects enamel formation. Mutations within MMP20 can lead to defects in enamel structure causing increased susceptibility to tooth decay and damage. Furthermore MMP20 interacts with other proteins involved in enamel anomalies like amelogenin aggrevating the condition's manifestations when dysfunction occurs.