Abcam, ab198846, Anti-HAS1 antibody

Size: 100µL
Rabbit Polyclonal HAS1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human HAS1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HAS1. The exact immunogen used to generate this antibody is proprietary information.Q92839

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HAS1 also known as hyaluronan synthase 1 is an enzyme responsible for synthesizing hyaluronic acid a major component of the extracellular matrix. The mass of HAS1 is approximately 63 kDa. HAS1 is expressed in a variety of tissues including connective tissues and some epithelial tissues. The enzyme plays a critical role in cellular mechanisms by directly converting substrates like uridine diphosphate (UDP)-glucuronic acid and N-acetylglucosamine into hyaluronic acid. This process makes it important for maintaining tissue hydration and structuring.
Biological function summary
HAS1 is involved in cell proliferation migration and differentiation processes. It contributes mainly to the synthesis of hyaluronan which acts as a significant component of the cell surface matrix. Though HAS1 functions independently its activity gets modulated by other proteins such as epidermal growth factor and transforming growth factor-beta. These associations emphasize its roles in dynamic cellular environments affecting the mechanical properties of tissues.
Pathways
The hyaluronic acid synthesis pathway heavily involves HAS1 along with other synthases like HAS2 and HAS3. HAS1 is a part of the broader glycosaminoglycan biosynthesis pathway. It shows interactions with other pathways such as the epithelial-to-mesenchymal transition where it correlates with proteins like CD44 and RHAMM. These pathways highlight the role of HAS1 in cell motility and tissue remodeling important in development and wound healing.
Aberrant regulation of HAS1 connects with pathological conditions such as cancer and arthritis. HAS1 expression levels can correlate with tumor progression as it affects the cellular environment conducive for metastasis. Additionally excessive production of hyaluronic acid by HAS1 associates with inflammatory disorders like rheumatic arthritis. In these conditions interaction with other proteins like matrix metalloproteinases exacerbates tissue degradation. This link demonstrates the impact of HAS1 on disease progression and identifies it as a potential therapeutic target.