Abcam, ab198892, Anti-FAT/FAT1 antibody

Size: 100µL
Rabbit Polyclonal FAT/FAT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FAT1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FAT1. The exact immunogen used to generate this antibody is proprietary information.Q14517

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAT/FAT1 also known as FAT1 cadherin is a large transmembrane protein encoded by the FAT1 gene. It has a molecular weight of roughly 506 kDa. This protein is characterized by its cadherin-like domains and is widely expressed in various tissues including the brain kidney and skin. FAT1 is involved in cell adhesion processes and plays a critical role in the maintenance of cell shape and polarity.
Biological function summary
This protein participates in development and morphogenesis. FAT1 functions as a part of the cell adhesion complex interacting with actin cytoskeleton components. It also influences cellular behavior such as migration and proliferation. Through its interactions FAT1 contributes to the mechanical stability and structural integrity of cells within tissues.
Pathways
FAT1 interacts with signaling cascades implicated in cytoskeletal reorganization and cellular communication. It is notably involved in the Wnt signaling pathway and the Hippo pathway which are key in cell proliferation and growth regulation. Other related proteins in these pathways include beta-catenin and YAP/TAZ which mediate the downstream effects of these signaling pathways.
Alterations in FAT1 expression or function have been associated with cancer and renal disorders. Mutations or dysregulation of FAT1 can lead to disrupted cellular processes contributing to tumorigenesis and kidney disease. It is closely connected to proteins such as p53 in the context of cancer where p53 plays a role in controlling cell cycle progression and apoptosis in response to genomic instability.