Abcam, ab199178, Anti-Connexin 30.3 / GJB4 antibody

Size: 100µL
Rabbit Polyclonal Connexin 30.3 / GJB4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GJB4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GJB4. The exact immunogen used to generate this antibody is proprietary information.Q9NTQ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Connexin 30.3 also known as Gap Junction Beta 4 (GJB4) is a protein that forms gap junction channels important for cell communication. This protein allows direct transfer of ions and small molecules between adjacent cells creating an essential connection for maintaining tissue homeostasis. Connexin 30.3 has a molecular mass of approximately 31 kDa and is expressed in various tissues including skin and nervous tissue.
Biological function summary
Connexin 30.3 plays a role in cell signaling and helps in maintaining the integrity of cell layers. It assembles into hexameric complexes known as connexons which dock with connexons from neighboring cells to form functional gap junctions. These channels facilitate communication among cells essential for processes such as differentiation and homeostatic regulation.
Pathways
Connexin 30.3 has significant involvement in the regulation of the calcium signaling pathway working closely with other connexins like connexin 43. Interaction within the gap junction communication pathway impacts various cellular responses including metabolic cooperation between cells. These pathways ensure coordinated cellular activities significant for overall tissue health.
Mutations in Connexin 30.3 can lead to skin disorders such as erythrokeratodermia variabilis. This condition involves impaired cell communication and abnormal keratinization of the skin. Additionally connexin 30.3 relates to hearing disorders as it shares functional pathways with connexin 26 and other connexins known to influence auditory functions. Proper understanding of these interactions aids in exploring therapeutic interventions.