Abcam, ab200363, Anti-MEG1 antibody - N-terminal

Size: 100µL
Rabbit Polyclonal MEG1 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Tyrosine-protein phosphatase non-receptor type 4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Tyrosine-protein phosphatase non-receptor type 4. The exact immunogen used to generate this antibody is proprietary information.P29074

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MEG1 also known as Maternally Expressed Gene 1 is an imprinted gene that plays important role in biological processes. The MEG1 gene product is a long non-coding RNA which does not encode proteins but participates in regulatory functions. It is usually expressed in the placenta embryonic tissues and certain adult tissues like the pituitary gland. The mass of the RNA transcript is not usually defined in non-coding RNAs but its size and structure allow it to perform specific activities within the cell.
Biological function summary
The MEG1 long non-coding RNA influences various cellular processes including growth regulation and developmental timing. MEG1 often functions within cellular complexes comprising a network of RNA-binding proteins that facilitate its role. The regulation of growth and embryonic development links MEG1 functionally to tissue differentiation. Its expression is tightly regulated suggesting a role as a molecular switch in growth pathways. Its influence on genomic imprinting maintains the balance of expression from maternal and paternal alleles ensuring proper development.
Pathways
MEG1 is involved in pathways that regulate cell growth and embryonic development. MEG1 interacts with key growth-regulatory pathways such as the Hedgehog signaling pathway. Proteins like SHH (Sonic Hedgehog) share these pathways illustrating how MEG1’s influence extends to various cellular contexts. There interactions fine-tune the balance of cell proliferation and differentiation emphasizing its role in development.
MEG1 is associated with disorders related to growth abnormalities and certain cancers. Aberrant MEG1 expression can lead to conditions like Silver-Russell syndrome and some types of cancers including neuroblastoma. MEG1’s connection to growth pathways links it to proteins like IGF2 which when misregulated contribute to these disorders. Disrupted expression patterns of imprinted genes like MEG1 or its pathway counterparts implicate it in complex disease mechanisms.