Abcam, ab200550, Anti-GTPBP1 antibody

Size: 100µL
Rabbit Polyclonal GTPBP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GTPBP1 aa 550-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GTPBP1 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.O00178

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GTPBP1 also called GTP-binding protein 1 plays important roles in cellular processes. It is a member of the GTPase family which hydrolyzes GTP to GDP. GTPBP1 has a mass of about 73 kDa. It is found in various tissues throughout the body with higher expression in the brain liver and testis. GTPBP1 is known to be localized in the cytoplasm and is associated with the ribosome.
Biological function summary
GTPBP1 participates in ribosome biogenesis and RNA metabolism being involved in quality control of ribosomal RNA processing. It is part of a complex that aids the maturation and function of ribosomal units. This protein has roles in maintaining ribosomal integrity and ensuring proper translation which are essential for cellular function.
Pathways
GTPBP1 engages in important processes involved in protein synthesis and mitochondrial function. It interacts with the ribosomal RNA processing pathway and plays a part in mitochondrial biogenesis. Related proteins in these pathways include GTPBP2 another GTP-binding protein involved in similar ribosomal functions and proteins in the mitochondrial fission and fusion dynamics.
GTPBP1 has associations with neurodegenerative diseases and immune system disorders. Its dysfunction can contribute to neurodegenerative conditions such as Parkinson's disease. GTPBP1 may interact with proteins like alpha-synuclein which is implicated in Parkinson's pathology. Additionally disruptions in GTPBP1 expression can impact immune system balance potentially leading to autoimmune conditions.